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Statistics Comparison between groups was calculated by student's t-test. For comparison of 2 groups over time a 2-way ANOVA followed by Bonferroni post-hoc test was used. Survival was calculated using Log-rank test. All statistical calculations were made using Graphpad Prism (La Jolla, CA, USA). A p valueHistone demethylase to control (Fig.?2A). Only animals that survived until final sacrifice were included in this weight comparison. Food and water consumption, measured periodically over the length of the study, were similar between groups (not shown). There were no differences in fat and lean body composition between groups when measured at 2, 12, and 17 months of supplementation (Fig.?2B). At final sacrifice, there were no significant differences in the weight of the heart, liver, pancreas, kidney, and gonadal adipose tissue (Table?1). Venetoclax datasheet One mouse in each group had hepatomegaly when they were sacrificed due to poor health. Fig.?2 Weight and body composition. Average weight (A) and lean and fat body composition (B) at different time points over the course of the study. Control represented by open bars and nitrate by green bars. Average weight consists of the 8 animals per group. ... Table?1 Final body weight and organ weight. Glucose and insulin tolerance tests Short-term dietary nitrate has previously been shown to improve glucose metabolism in endothelial NO synthase (eNOS) deficient mice with features of metabolic syndrome [29]. To see if there were any differences in glucose handling, intraperitoneal glucose tolerance tests (IPGTT) were run periodically throughout the experiment. There were no differences in the area under the curve of Enzalutamide mouse IPGTTs performed at 5, 7, 10, 14 and 17 months of treatment (Fig.?3A) (5 month results shown in Fig. 3B). This held true for the fasting glucose levels (Control 7.34��0.14?mmol/L vs Nitrate 7.45��0.14?mmol/L; p=0.563). An intraperitoneal insulin tolerance test at 17 months of treatment showed improved insulin responsiveness in the nitrate treated group as measured by percent change from basal glucose level (Fig.?3C) and area under the curve of the individual tests (Fig.?3D). Fig.?3 Glucose and insulin tolerance tests. Area under the curve (AUC) of the intraperitoneal glucose tolerance test (IPGTT) as a percentage of the 5 month IPGTT in control animals (A), and group average IPGTT curve at 5 month of supplementation (B). Intraperitoneal ...