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2. Methods 2.1. Study Design and Patients This was a real-life study in which patients with autoimmune diseases, undergoing GC therapy, followed up at the Outpatient Clinic of the Systemic Autoimmune Diseases Unit at San Cecilio Hospital in Granada (Spain) (a university teaching hospital), between January 2010 and September 2013 were assessed. The study was approved by the Clinical Research Ethics Committee of the San Cecilio Hospital. All participants gave their written consent in accordance with the Declaration of Helsinki. 2.2. Inclusion Criteria The inclusion criteria included patients 18 years old and older who have been on GC therapy, for Alizarin more than three months before the date of recruitment, and who were expected to continue receiving glucocorticoids in a stable dose, because of the underlying autoimmune disease, for at least another three months, and in whom their doctor had indicated the use of calcidiol or cholecalciferol for the prevention of GIO. 2.3. Exclusion Criteria The exclusion criteria included patients who had been treated with Selleck Fulvestrant 6-methylprednisolone pulses or who required higher doses of prednisone 15?mg/d for disease control, and those suffering from other diseases such as neoplasia, liver disease, hyperparathyroidism, hypercalcemia, hypercalciuria, hypophosphatemia, or renal insufficiency (creatinine levels >1.5?mg/dL) were excluded. 2.4. Procedure At the time of inclusion relevant clinical data including the dose of GC and the drugs used to avoid the potential bone mass loss mediated by GC, including type of vitamin D supplement (cholecalciferol or calcidiol), was assessed. At each visit, clinical data related to the patient's disease, as well as his/her adherence to the indicated treatment, were recorded. The interval between two visits was not longer than 6 months with a follow-up of one year. The average prednisone dose was calculated by dividing the accumulated prednisone dose between the days of follow-up. Laboratory determinations in fasting selleck compound conditions were done at inclusion. During follow-up, 25(OH)D levels were also measured. At least two determinations were obtained for each patient, one during spring-summer (from April 1 to September 30) and another during fall-winter (from October 1 to March 31). We established the mean 25(OH)D level for each patient considering the values obtained in both periods. Regarding vitamin D, values ��30?ng/mL were considered optimal and values