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95, 95% CI 0.79�C1.13, I2=0%). Figure 7 Internet interventions compared to telephone counseling. Internet interventions compared to other websites Twenty-three trials compared Internet interventions to other web-based interventions. Excluded from this analysis were the studies by Bricker et al50 and Berg et al61 (pilot studies focused on feasibility, no power analysis was conducted); Etter,63 Herbec et al,59 and Strecher et al56 (primary outcome assessed at KU55933 results for the remaining 15 trials (24 comparisons) found a significant effect in favor of Internet interventions compared to other websites (RR 1.16, 95% CI 1.03�C1.31, I2=76.7%). The forest plot is presented in Figure 8. Two trials with college students in the study by An CYTH4 et al40,78 showed significant effects for the two experimental conditions over the control condition, and for a personally tailored website with peer coaching over the personally tailored website alone. In the study by Stanczyk et al,74 there was a significant effect of the computer-tailored video-based website over a static website with general information. Of the remaining 19 comparisons, eleven showed nonsignificant effects in favor of the experimental condition, with RRs at or below 1.34. In the study by McClure et al,54 three of the four comparisons favored the more intensive/experimental factor over the control. Nonsignificant effects in favor of the control arm were observed in the studies by Graham et al,66 Mason et al,72 McClure et al54 (email factor), Mu?oz et al68 (static website + email vs static website), Mu?oz et al37 (study 3 and study 4), Stoddard et al,77 and Wangberg et al.22 Figure 8 Internet MK-1775 ic50 interventions compared to other websites. Discussion The goal of this systematic review was to evaluate the literature regarding the effectiveness of Internet cessation interventions, with particular reference to other cessation interventions supported by treatment guidelines. We reviewed 40 randomized trials that included 98,530 participants published from January 1990 through April 2015. These studies varied considerably with regard to the intervention features, comparison conditions, participant characteristics, and cessation outcome.