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01). On the other hand, no statistical difference was observed for total IgE serum values in athletes with different allergy phenotypes or different sensitization patterns. This study shows that specific IgE determination using the ImmunoCAP ISAC microarray technology may provide useful additional information to those provided by conventional IgE tests in athletes with multiple positive skin tests. The correlation between ISAC and ImmunoCAP sIgE or skin tests was quite high for the four main allergens considered. In fact, PPA between ISAC and ImmunoCAP sIgE ranged between 85% and 95% in case of a clearly positive ImmunoCAP sIgE (above 1?kUA/l), while the NPA ranged between 89% and 100% in case of a clearly negative ImmunoCAP sIgE (learn more above 0.3?ISU was found in some nonallergic control athletes only for a few molecular allergens in the lack of any clinical symptom. This should prompt the manufacturing company to check the nonspecific binding of some molecular allergens included in the ISAC microarray (mainly Equ c 3, Bla g 1 and Gly m 5). However, rather than focusing on the already buy Nutlin-3a reported very good correlation between ImmunoCAP ISAC and skin tests or ImmunoCAP specific IgE, we prefer to focus on the potential significance of discordant cases, as well as on the potential added value of distinguishing among different patterns of sensitization. The correlation between the presence of specific IgE to at least one ISAC allergen and a positive skin test to the corresponding extract-based allergen was higher in athletes with clinical symptoms (96%) than in athletes with positive skin tests but who were asymptomatic (75%). This might indicate a higher sensitivity of skin tests to detect sensitization but a higher specificity of ImmunoCAP ISAC to detect clinical allergy. The Oxymatrine correlation of ImmunoCAP ISAC vs skin tests or ImmunoCAP specific IgE for detecting specific IgE against a major specific allergen component varied among allergens. This might imply a different prevalence of sensitization to major allergen-specific components for different allergens and the fact that crude allergen extracts commonly include also other known and unknown specific or nonspecific components. For instance, PPA was higher for grass (represented on the chip by almost all major allergen components) than for Parietaria, which contains several allergen components not present on the chip apart from Parj2, profilin and CCD. However, a more interesting and unique advantage of component-resolved diagnostics stands in the possibility of providing a fingerprint of sensitization in subjects with a similar sensitization to multiple allergens at skin tests or at other extract-based assays of specific IgE.