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Ease of use The documented benefits of negative pressure wound therapy are known to include reduction in the number of required dressing changes and in nursing time.38 A previous randomized controlled trial of the SNaP negative pressure system versus the commonly used VAC (KCI?) system indicated that the mean application time for SNaP was significantly less (pcheck details perform debridement if required, and to reapply compression bandages if necessary. As such, this could be viewed as the additional time required than that of a standard dressing change. It is evident from this time that the application of the SNaP device is not a lengthy process, which would suggest that the device is relatively easy to use. Consideration should also be given to the fact that it is only performed on average twice weekly. For highly exuding wounds, for example, dressing changes may be required daily or on alternate days, which may significantly increase the demand on nursing time and resources in the initial treatment period. The time taken Selleckchem PD173074 to apply the dressing and achieve a seal on the foot ulcer wounds was ?5?min longer than that taken for the venous leg ulcer patients. This is understandable as the foot wounds are usually in a much more difficult position to dress than leg ulcers, meaning it could take longer to achieve an effective seal. Foot ulcers can often be time-consuming and difficult to dress with standard dressings. Also, the times for the neuropathic foot wounds would have increased the mean application time of the MRIP entire cohort; therefore, the ?6?min taken for the venous leg ulcer patients is much more reflective of the short time needed to apply the SNaP device in this cohort of patients. Effect on quality of life These results suggest that use of the SNaP Wound Care System can positively impact on the quality of life experienced by patients with chronic wounds. This reflects outcomes displayed in the literature regarding the effect of using TNP therapy on the quality of life of patients with wounds,24,39 although the general consensus is that more research is required in this area. Results also need to be interpreted with caution as the CWIS has been validated to highlight changes in quality of life when performed at least 12 weeks apart, whereas here there was only a 6-week period between questionnaires. It has also been documented that purely participating in a clinical trial can lead patients to report an improvement in their state of health.