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014) (Fig. 1). However, none of the between-group differences were greater than 5 points at any time point, indicating no clinically significant difference between groups.17 Fig. 1. Psychometric PORPUS-scores (mean and standard deviation) at each time point. Baseline questionnaires plotted at month 0. The response rate for the completed PORPUS-P scores Selleckchem Palbociclib at each time point was: baseline (n = 437 ORP, n = 210 RARP), 3 months (n = 399 ... Predictors of baseline HRQOL On univariate analysis, increased age, higher Gleason score, higher BMI, and higher PSA level were associated with decreased PORPUS-P scores at baseline (preoperatively) (p analysis, type of RP had a significant effect on PORPUS-P at the 3-month period after adjusting for other predictors Cofactor (p = 0.038). The mean difference between RARP and ORP was 3.262 points. Type of RP also had a significant effect at the 9-month period after adjusting for other predictors (p = 0.037 mean difference 3.78 points) (Table 3). Type of RP did not have a significant effect at 6, 12, or 15 months. None of these differences met previously defined thresholds of clinical significance. Table 3. Univariate analysis of changes to PORPUS-P IIEF scores We illustrated the trends in mean (�� standard deviation) IIEF scores (the IIEF-5 score is the sum of the ordinal responses to the 5 items: (1) 22�C25: No erectile dysfunction; (2) 17�C21: Mild erectile dysfunction; (3) 12�C16: Mild to moderate erectile dysfunction; (4) 8�C11: Moderate erectile dysfunction; and (5) 5�C7: Severe Everolimus datasheet erectile dysfunction) over time for the RARP and ORP (Fig. 2). IIEF scores were not significantly different between groups at baseline. They were significantly higher in the RARP group at 3 months (7 �� 4 ORP, 9 �� 6 RARP, p = 0.001) and 12 months (10 �� 6 ORP, 12 �� 7 RARP, p = 0.011), although none of the differences were clinically significant (i.e., all were smaller than the minimum clinically important difference). Fig. 2. Mean (�� standard deviation) IIEF scores at each time point. Baseline scores plotted at month 0. The response rate for the completed IIEF questionnaires at each time point was: baseline (n = 364 ORP, n = 187 RARP), 3 months (n = 219 ORP, n = 148 ... IPSS Scores We illustrated the trends in mean (�� standard deviation) IPSS scores (IPSS score categories: (1) 1�C7: Mild; (2) 8�C19: Moderate; and (3) 20�C35: Severe) over time for the RARP and ORP (Fig. 3). IPSS scores were not significantly different between groups at baseline. IPSS scores were statistically significantly lower in RARP patients compared to ORP patients at 3 months (11 �� 7 ORP, 9 �� 6 RARP, p = 0.04), 6 months (8 �� 6 ORP, 6 �� 5 RARP, p
