What To Anticipate From UMI-77?

001). The distribution of genotype combinations between the three SNP resulting from the best MDR model is depicted in Figure?1a. The genotype combinations of AG, CC and CA of 46A/G, 79C/G and 523C/A are the most common combinations and the ratio indicates high-risk combination (cases/controls?��?1). The homozygote combinations consisting of AA, CC and CC for the above SNP were categorized as high-risk combinations. The dendrogram (Fig.?1b) highlights the overall interaction information gained for all the SNP. The black line connecting two polymorphisms suggests a synergistic or non-additive relationship, while the light-gray line suggests redundancy. A strong Nintedanib synergistic effect is seen between SNP ?367C/T and 79C/G, and a weaker synergistic effect between ?654A/G CYTH4 and 46A/G. Haplotype association tests were performed at a cut-off frequency of >2%. To understand the relationships among the eight SNP, we first assessed the pairwise LD measured by D��. The three promoter polymorphisms were in strong LD in both HAPE-p and HAPE-r (Fig.?S1 in the online supporting information). Overall, a stronger LD was observed for most of the SNP in HAPE-p. A total of 43 haplotype combinations were generated for the eight SNP in both HAPE-p and HAPE-r, of which only 12 exceeded the frequency limit of >2% (Table?3). These 12 haplotypes comprised ?86% of all the haplotypes in this population. The remaining haplotypes were grouped as M (Table?3). The labelling of haplotypes was essentially based on a previous report,32 that is, H1 to H10. The haplotype H6a was the most common haplotype and H10 was completely absent among the HAPE-p (��2?=?9.96, P?buy UMI-77 haplotypes were more frequent in HAPE-r (17.6%) than HAPE-p (9%) (��2?=?7.57, P?=?0.006, OR?=?2.17, with 95% CI: 1.24�C3.8). As indicated in Table?3, the omnibus haplotype tested for these SNP showed significant association with HAPE (LR��2?=?86.69, P?