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However, in HRV-positive patients without an underlying pulmonary illness, only cough and fever were significantly more present (Table?3). In multivariate analysis, the presence of a chronic respiratory disease remained positively associated with HRV mono-infection (OR, 2.06; CI, 1.43�C2.97). This association was unique for HRV mono-infections and was not found for HRV mixed infections or other respiratory viral infections. Besides, in patients with a chronic respiratory illness a Chk inhibitor need for oxygen was exclusively related to HRV detection (odds ratio 3 for HRV mono-infection, and 3.3 for mixed infection). Cough and shortness of breath were equally strongly associated with the detection of other respiratory viruses as with HRV (Table?4). Patients with an HRV infection were more often diagnosed with an exacerbation of asthma compared with PCR negatives and patients with another respiratory virus, Quizartinib mouse although the difference with the latter group was not statistically significant (Table?5). In contrast, pneumonia and bronchiolitis were more often associated with the detection of respiratory viruses other than HRV. The median length of stay in the hospital was significantly shorter for patients who had any respiratory virus compared with patients with no virus (7?days vs. 25?days, p?Sitaxentan (in 52% of PCR negatives, 50% of those with HRV and 53% with another respiratory virus, antibiotics were given). Also, the duration of antibiotic therapy was comparable (median duration of 7?days). In more than 60% of the disease episodes, no bacteriological culture was recorded around the time the virological sample was taken. When bacteriological cultures were taken, significantly more H.?influenzae was found in patients with HRV (17.4%, p?0.04) and in patients with another respiratory virus (19.4%, p?0.02) compared with the patients who had no respiratory virus detected (3.6%). S.?pneumoniae was more often found in patients with another respiratory virus (19.4%) than in patients with HRV (2.2%, p?0.02). The use of antibiotics was strongly associated with the clinical diagnosis of pneumonia and the submission of samples for bacteriological culture: antibiotics were prescribed in 94% of the patients with pneumonia and in 75% of patients who had samples collected for bacteriological culture (both p?