We hypothesized that increased cytotoxicity, reduced cell viability, and reduced proliferation after treatment with PCT analogs could be due to inhibition

Cells ended up treated with motor vehicle, PCT analogs, and PCT analogs with click here several doses of 50 nM PFT. Western blots displaying inhibition of p53 by PFT at 72 h in TM-025 and TM-026 (fifty nM) treated SCC25 cells. (E) Bar graph shows % S-phase cells soon after cell cycle analysis of PI-stained cells. Outcomes displaying substantial modifications are denoted by (P670220-88-9 vehicle treatment) to 15% and 12% in SCC104 cells, after 24 h of treatment with 1 nM of TM-025 and TM-026, respectively (Fig 6A and 6C and S1 Table).