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To be included in the outcome study of a patient with encephalitis of unknown aetiology, the following inclusion criteria had to be met: signs and symptoms of encephalitis/encephalopathy with quantitative or qualitative impairment of level of consciousness for more than 24?h duration and at least one of the following signs VX809 or symptoms: body temperature of >38.0��C, seizure, focal neurological signs, cerebrospinal fluid (CSF) pleocytosis, or neuroradiological or neurophysiological signs of encephalitis. Exclusion criteria were: (i) age 3?weeks before hospitalization; (iii) HIV infection; (iv) chronic inflammatory systemic disease or neoplasia; (v) abuse of intravenous drugs or alcohol; (vi) a diagnosis of migraine with aura; (vii) residence in Switzerland for Carfilzomib manufacturer (ii) a questionnaire for attention deficits [11]; (iii) the short version of the Geriatric Depression Scale [12]; and (iv) the Epworth Sleepiness Scale [13]. Outcome was defined as ��healed�� if the patient was alive, there were no signs and symptoms of encephalitis, and the neuropsychological test results were normal. ��Deficit�� was defined as any abnormal neuropsychological test result or overt neurological deficit. Death was categorized based on clinical judgement as either the result of encephalitis or unrelated causes. Statistical analysis was performed with statview, version 5.0 (SAS Institute Inc., Cary, NC, USA). Proportions were compared with the chi-square test or Fisher��s exact test as appropriate. Differences between Cefaloridine means were assessed by Student��s t-test. p?��?0.05 (two-tailed) was considered statistically significant. Of the 149 patients with a discharge code that did not suggest an obvious aetiology, sixteen were excluded because they were