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CON, UVB-p21+ vs. p21+, UVB-p21�C vs. p21�C, p downregulated compared to CON cells (p21�C vs. CON, pVeliparib concentration was significantly increased across all experimental groups (UVB-CON vs. CON, UVB-p21+ vs. p21+, UVB-p21�C vs. p21�C, p to that of UVB-CON (UVB-p21+ vs. UVB-CON, plazabemide 4B), while the apoptosis rate in UVB-p21�C cells was significant upregulated compared to UVB-CON cells (UVB-p21�C vs. UVB-CON, pDAPT in vitro in UVB-irradiated HaCaT keratinocytes but promotes apoptosis in non-irradiated HaCaT keratinocytes. Figure 4 Apoptotic activity by flow cytometry. (A) Flow cytometric analysis of apoptosis. (B) Percentages of apoptotic cells before and after UVB irradiation. With no irradiation, both p21 overexpression (p21+) and p21 silencing (p21�C) had a pro-apoptotic ... p21��s effect on HaCaT keratinocyte proliferation In non-irradiated cells, loss of p21 resulted in suppression of proliferation rates (p21�C vs. CON, p0.05; Figure 5). Proliferation of UVB-p21+ cells was more obviously suppressed compared to UVB-CON cells (UVB-p21+ vs. UVB-CON, p