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Results:? Children had a median age of 4?years (0.53�C13.21?years) and weight 15.7?kg (7.5�C52?kg). PK of etomidate was best estimated using a three-compartment model with weight on systemic (Cl1) and inter-compartmental clearances (Cl2, Cl3), central (V1), and peripheral compartment volumes (V2, V3). The most significant PK covariate CP 868596 was age, with increasing age having reduced size-adjusted Cl1, V1, and V3 (all P?buy GW-572016 perioperative management of sickle cell disease. Results:? The response rate to valid addresses was 25% (n?=?510/2006). In four scenarios, (a patient with mild disease undergoing a minor procedure; a patient with mild disease undergoing a more invasive procedure; PTPRJ a patient with severe disease undergoing a minor procedure; and a patient with severe disease undergoing a more invasive procedure) 80%, 38%, 27%, and 16% of respondents, respectively, would rely on oral fluids to hydrate patients during the preoperative fast, while 13%, 34%, 44%, and 59%, respectively, would use intravenous fluid. For the same four scenarios, 64%, 28%, 33%, and 10%, respectively, would not transfuse patients in an attempt to prevent sickle cell exacerbations, while 17%, 49%, 36%, and 51%, respectively, would transfuse to a hemoglobin concentration of 10?g��dl?1. The tendencies to administer preoperative intravenous fluid and to transfuse blood increased with disease severity and procedure invasiveness (P?