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Hypophosphatemia was considered moderate when the phosphate level ranged between 0.32 and 0.80?mmol/L and severe when the level was less than 0.32?mmol/L. 2.1. Statistical Analysis Results are expressed as mean �� standard deviation. Comparisons were done using a t-test. p Quinapyramine 130 patients were included: 52 were treated with FS injection (17 men, 35 women) and 78 with FCM injection (24 men, 54 women). 3.1. Iron Sucrose Among the 52 FS-treated patients, the mean dose of FS was 701?mg (quartile 200�C800). Patient mean age was 55 �� 21 years. Iron was prescribed by hematologists (5 patients), geriatricians [2], gastroenterologists find more [4], nephrologists [1], oncologists [4], internists [3], pediatricians [2], and gynecologists [1]. Indications for FS injection were IDA in 40 cases and ID in 6 cases and 3 patients had no anemia and no ID. Moreover, 3 patients received FS injection while their hemoglobin level and iron status were not assessed. Patient characteristics are presented in Table 1. Forty patients were asymptomatic, 12 presented with fatigue, and 3 complained of dyspnea. One patient had anemia-related vertigo. The mean hemoglobin level before injection was 10.1 �� 1.99?gr/dL and it increased to 11.5 �� 2.3?gr/dL after iron administration (p = 0.02). The mean ferritin level rose from 64?��g/L (quartile: 6�C61?��g/L) to 133?��g/L (34�C139?��g/L) (p = 0.08). No difference in ferritin level or in hemoglobin level was noted between patients with and without fatigue (p = 0.63 and p = 0.6 for the ferritin and hemoglobin level, resp.). Before Selleckchem Neratinib intravenous injection, 42% of patients had taken oral iron formulation which was ineffective and led to digestive intolerance in 54% and 31% of cases, respectively. The initial phosphate level measured was 1.08 �� 0.23?mmol/L and it did not change significantly following FS administration (1.00 �� 0.29?mmol/L; p = 0.37). Before injection, 4 patients had moderate hypophosphatemia and none had severe hypophosphatemia. After injection, 22% of patients developed hypophosphatemia with a phosphate level less than 0.80?mmol/L (they were all within normal range before injection). The lowest value after administration was 0.44?mmol/L. Hypophosphatemia duration varied between 2 and 18 weeks. However, the long-term phosphate level was not systematically assessed. No clinical manifestations of hypophosphatemia were found in the medical records. After injection, the phosphate level did not correlate with the initial hemoglobin level (rs = 0.153, p = 0.5), ferritin level (rs = 0.05, p = 0.82), or cumulated injected iron doses (rs = 0.2, p = 0.37).
