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1). Figure 1 Western blot analysis for human HL immunoreactivity. Expression of human HL in postheparin plasma from hl?/? ciHL (Left panel) and hl?/? hHL mice (Right panel) were assayed by Western blot using a monospecific antihuman ... Table 2 Hepatic lipase activities in pre and postheparin plasma1. Genotype differences in body weight and body fat mass Body weight at baseline was similar among the three genotypes, HL-deficient mice alone or expressing either intact hHL or catalytically inactive ciHL (Table?(Table3).3). However, following exposure to HFD for three months, male hl?/? mice rescued with transgenic expression of intact hHL (possessing both the catalytic and bridging functions) had significantly higher body weight (?15%) than either male mice Idelalisib supplier rescued with inactive ciHL (which contains the bridging function, but is catalytically inactive) or hl?/? male mice alone (P?Ficain metabolic responses to High-fat diet challenge. In female hl?/? mice, rescue with transgenic expression of intact hHL also resulted in significantly increased body weight (11%) relative to those rescued with inactive, ciHL (P?=?0.05) (Table?(Table22 and Fig.?Fig.2).2). In addition, Small molecule library manufacturer there was a trend toward increased body weight gain in hl?/? mice rescued with intact hHL relative to mice rescued with the inactive ciHL (Table?(Table3).3). Historical data from female WT mice with intact murine HL activity demonstrated a similar weight gain to the hHL-expressing mice (Table?(Table3)3) (Chiu et?al. 2010). Taken together, these findings demonstrate that the HL catalytic function rescues the lean phenotype of hl?/? mice although this effect is more pronounced in male than in female mice. Figure 2 The catalytic function of human HL rescues the lean phenotype of HL-deficient mice. HF-fed hl?/? hHL (filled diamonds), hl?/? open diamonds) and hl?/? ciHL (open squares) male (A, B) and female (C, D) mice. ... To determine whether these differences in body weight were due to changes in lean mass, fat mass or both, we performed body composition analysis. The increased body weight in HFD-fed male hl?/? mice rescued with intact HL was characterized by an increase in body adiposity relative to either hl?/? mice or hl?/? mice-expressing ciHL (Table?(Table3).3). In female mice a similar but weaker trend was seen (Table?(Table3).3).