Unanswered Queries Around Neratinib Disclosed

14 The availability of targeted therapy for patients with lung cancer over the past decade has transformed the management of this persistently lethal disease, moving clinicians from rigid protocols into personalized treatment. David Lam reviewed the current applications of molecular testing that have ushered in personalized care for lung cancer, including testing for the epidermal BMS-777607 mw growth factor receptor gene mutations and the anaplastic lymphoma kinase gene rearrangement.15 Screening for lung cancer remains an area of continued debate, even though recent screening trials provide support for computed tomography screening in selected populations. Stephen Spiro and Neal Navani provided a comprehensive review on the current progress of various screening studies in lung cancer.16 Mitsuo Sato and colleagues RVX-208 selected a frontier area of scientific research in lung cancer��epithelial mesenchymal transition��for review.17 Recent research into sleep-related breathing disorders has provided extensive data in support of translational knowledge. Romola Bucks and colleagues authored an in-depth review on our current understanding of neurocognitive aspects of obstructive sleep apnoea.18 Macy Lui and colleagues discussed the importance of endothelial dysfunction in obstructive sleep apnoea.19 Fang Han reviewed a sometimes neglected yet important area of sleep medicine research,20 namely narcolepsy and cataplexy, helping physicians develop practical approaches to these increasingly recognized clinical problems. Francoise Roux reviewed yet another often check details under-diagnosed sleep-related breathing disorder, that is, restless leg syndrome.21 The aforementioned topics represent only a small sliver of the translational clinical research that is increasingly informing our broad field of respiratory medicine. Conditions left out include interstitial lung disease, bronchiectasis and cystic fibrosis to name but a few. The manuscripts published in this series, however, create a clear image of the new landscape for research and clinical practice that is moving knowledge from the bench to the clinic along a remarkably streamlined trajectory. We hope to revisit this topic in future editions of Respirology to catch up on how other respiratory conditions have benefited from translational research as well. In the meantime, we thank the authors of the present series for sharing their expertise and setting us off on a course towards a more rapid translation of science to improved patient care. ""5069" "Background and objective:? Accurate staging at the time of diagnosis is very important in deciding on the appropriate treatment for cancer patients. FDG PET indicates metabolic changes in cancer cells, enabling the early detection of lesions.