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In four patients from the study group (two of whom had secondary infection) the decision was taken to continue the antibiotic treatment irrespective of the PCT levels, therefore, the data of these buy INK 128 patients were also excluded from statistical analysis. Ultimately, a total of 46 Burn ICU patients receiving antibiotic therapy were enrolled in the study (47.7��19 years, 74% males, 35.5��16% TBSA, 10.5��4 APACHE II, 23��10 SAPS II, 3.9 ��2 SOFA score). In 24 patients, antibiotic therapy was guided by daily PCT and clinical assessment. The control group was comprised of 22 patients with a standardized duration of antibiotic therapy. The mortality rates of PCT group and control group patients were 25% and 36%, respectively. Multiple organ failure due to septic complications was the main cause of death. Concentrations of PCT at admission and maximum PCT levels during the infection were 0.69 (0.3-1.4) ng/ml, and 7.8 (0.3-13.9) ng/ml, respectively. Demographic and clinical data were comparable in both groups ((Table I). Patients in the control group had a higher incidence of pneumonia diagnosis (20.8% vs. 36%) and were slightly older (42.9��18 vs. 51.1��17, years) than in the investigation group. Table I Patients�� demographic and clinical baseline characteristics The main bacterial strains responsible for infections were Gram-negative bacteria, Pseudomonas Capmatinib price Aeroginosa, Acinetobacter baumannii and Klebsiella pneumonia, which had a high percentage of MDR bacteria (47.7%). Multidrug-resistant strains were isolated in 61% of surviving patients from the investigation group and in 54.5% of the surviving control group patients after the discontinuation of the antibiotics. The duration of antibiotic therapy was significantly shorter in the PCT-guided therapy group compared to the control group without negative effects on clinical outcome (Table II). The duration of antibiotic therapy was also significantly shorter in patients with pulmonary infection (10.4��2.3 vs. 13.1��6, days, p=0.05). PCT guidance resulted in a smaller overall antibiotic exposure during the first 28 days of ICU stay (Table II). After performing univariate analysis to correct for confounding factors, we found that the presence of comorbidities had influence on the duration Quinapyramine of antibiotic therapy with p value of 0.044. Table II Patients�� outcome characteristics Non-survivors on ICU discharge were older than survivors (66��11 vs. 42��18 years, p=0.014), had a higher percentage of septic shock (91% vs. 15%, p
