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026). No differences in p53 immunoreactivity were observed between subtypes. None of tumor cells were immunoreactive with c-kit. The mast cell counts showed a negative correlation with mitosis and tumor size (P?Everolimus clinical trial predict the clinical prognosis. Mast cells that perform diverse functions in various conditions [4] can infiltrate around tumor cells in various cancers [5-8], and it is suggested that complex and multiple functions of mast cells are important in tumor growth and progression. The purpose of this study is to evaluate the utility of p53, SMA and c-kit as prognostic immunohistochemical markers, which could correlate with the clinical outcome. Moreover, we investigated role of mast cells in pathogenesis of the tumor. For details of methods, see the Data Cilengitide S1. We analysed data for 31 patients, and Table S1 summarizes the clinical this website characteristics of the 31 patients who had DFSP. A total of 32 lesions from 31 patients were enrolled. On slide review of the 31 patients, most of the cases showed conventional histopathological features with dense and uniform proliferation of spindle-shaped tumor cells in a storiform arrangement. The next most common forms included myoid, myxoid, pigmented and fibrosarcomatous transformation (DFSP-FS) (Table S2, Fig. S1a�Cd). There were two cases of DFSP-FS that had areas of cellular fascicles with a herring-bone pattern and cells with pleomorphic nuclei and numerous mitoses. Among them, one case of DFSP-FS coexisted with myoid differentiation. DFSP-FS tended to invade more deeply (P?=?0.042) and be of larger size (P?=?0.026) than other subtypes. All cases of DFSP-FS were sized over 4?cm, but only 11.5% of other subtypes exceeded that size. Except for invasiveness and size of tumor, differences in the clinical manifestation including age, site, local recurrence rate and metastasis according to histological subtypes were not observed. Most authors concluded that DFSP-FS has a higher tendency to have a definite risk of recurrence and metastasis than classic DFSP [3, 9]. We could not find a direct correlation between DFSP-FS and a poorer clinical outcome, but as tumor size and invasiveness was relatively associated with frequent local recurrence in previous research [9], the results of the present series are in line with previous observations.