To Opportunity Seekers Who Want To Understand Hesperadin But Fail To Get Rolling

7��12.6 years. No significant difference was identified between the groups regarding age (P=0.549). The genotype and allele frequencies of the pri-miR-34b/c Hesperadin rs4938723 T>C polymorphism in the BC patients and healthy women are shown in Table I. The results indicated that the rs4938723 polymorphism was not significantly associated with the BC risk in the codominant (TC vs. TT: OR, 0.87; 95% CI, 0.60�C1.26; P=0.506; CC vs. TT: OR, 1.22; 95% CI, 0.61�C2.47; P=0.600), dominant (TC+CC vs. TT: OR, 0.91; 95% CI, 0.64�C1.31; P=0.648), recessive (CC vs. TT+TC: OR, 1.32; 95% CI, 0.67�C2.59; P=0.498) and overdominant (TC vs. TT+CC: OR, 0.84; 95% CI, 0.59�C1.21; P=0.361) inheritance models tested. Furthermore, the rs4938723 C allele was not a risk factor for BC (OR, 0.99; 95% CI, 0.75�C1.31; P=0.986). Table I. Association of the pri-miR-34b/c rs4938723 T>C polymorphism and risk of breast cancer. The genotype of the polymorphism in the controls and cases were in Hardy-Weinberg equilibrium (��2=3.49, P=0.061 and ��2=0.227, P=0.624, respectively). Associations between the variant and clinicopathological characteristics The association between the pri-miR-34b/c rs4938723 variant and clinicopathological characteristics, including age, body mass index (BMI), tumor size, tumor stage, tumor grade, lymph node metastasis, estrogen and progesterone receptors (ER ABT-737 in vitro and PgR), and human epidermal growth factor receptor 2 (HER2) are shown in Table II. The results showed a significant association between the pri-miR-34b/c rs4938723 variant and grade, PgR and HER2 status of BC patients (Pfind more identified between the rs4938723 polymorphism and age, BMI, tumor size, lymph node metastasis, stage and histological type of BC patients (P>0.05). Table II. Correlation between the miR-34b/c rs4938723 T>C genotypes and clinical characteristics of breast cancer patients. Discussion The present study investigated the impact of the pri-miR-34b/c rs4938723 polymorphism on the BC risk in a sample of the Iranian population. The data showed that the rs4938723 variant of pri-miR-34b/c was not associated with the risk of BC population. By contrast, a significant association was identified between the pri-miR-34b/c rs4938723 genotypes and clinicopathological characteristics, such as grade, PgR and HER2 status (P