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Questions were chosen for good selleck chemicals llc face validity and selected on the basis of relevance. Six questions were considered relevant for the FAIM-CF and -AF and five questions were considered relevant for the FAIM-TF. The FAIMs showed good reliability with ICCs and CCCs above 0.70 and with mean differences all close to zero. There was little evidence for scale shift and location shift supporting the accuracy of the FAIM. Generally, independent measures used to validate HRQL questionnaires are some sort of objective measurement of the severity of a disease. An objective measurement is often related to the burden of symptoms characterizing the disease. However, in food allergy, no such clinical measure based on symptoms exists. Moreover, such a clinical measure Tolmetin would even be inappropriate because food allergic patients only experience symptoms on accidental exposure, while their HRQL is continuously affected by their condition. An independent measure based on food allergic outcomes attempts to capture the aspects of disease severity, which drive HRQL in an ongoing way. HRQL instruments built upon the method of EO questions have proved to be useful and consistent in measuring HRQL (5, 13). It was an unexpected finding that in adolescents EO question 3 was not correlated with any of the items of the FAQLQ-TF. As this question has successfully been used before in other age groups, we expected the question to be valid and relevant. However, this finding might indicate that adolescents are not afraid of dying of anaphylaxis and underestimate exposure in contrast to adults and children. Previously, it has been reported that Selleck DAPT secretase adolescents perceived their anaphylaxis as ��no big deal�� (14) despite the fact that they are at the highest risk of dying from food allergy (15). Another remarkable finding was shown in the results of the validity of EO question 4. These results illustrate that the wording of a question is very important. Changes in wording may result in misreading of the question or misdirection of the answer in sometimes unexpected ways. According to the reliability results, the FAIM-AF showed the lowest ICC and CCC and the widest limits of agreement. This may have been caused by two outliers in the FAIM-AF. This assumption was supported by a re-analysis excluding the two outliers, which showed an ICC of 0.84 (P?