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Informed consent was obtained from all participants. The ethics committee and Institutional Review Board of Tehran University of selleck Medical Sciences approved this study. Patients who met the inclusion criteria were asked to sign an informed consent form after a thorough explanation of the risks and benefits of the procedure and alternate options for treatment. Patients were randomized to undergo either a hinged capsulotomy (hinged group) or conventional circular capsulotomy (conventional group) [Figure 1]. Patients were masked to the type of capsulotomy they received until the end of the study. Data were collected on patient demographics and characteristics of the procedure such as the number of spots, delivered energy, and the size of the capsulotomy. Figure 1 Schematic of the process of capsulotomy in each group. The dotted white line indicates the capsulotomy border In both groups, tropicamide 1% (Sina Darou, Tehran, Iran) was administered 20 min before the procedure. The same ophthalmologist http://www.selleckchem.com/products/LBH-589.html performed Nd-YAG capsulotomy with a YAG laser (Carl Zeiss, Jena, Germany) for all cases. In the hinged group, an incomplete circle maintaining an inferior 90�� hinge was performed. In the hinged group, the attachment of the capsule was maintained inferiorly, with the attachment acting as a hinge for the remnant of the capsule. In both groups, the lowest energy setting was selected that was effective at disrupting the PCO. Postoperatively, topical betamethasone and timolol were prescribed to all patients for 1-week. IOP was checked 2 h after the procedure and cases with increased IOP were treated with antiglaucoma medication as warranted. One-month postoperatively, a complete ophthalmic examination was performed including measurement of corrected and uncorrected vision, and measurement of the size of the opening on the posterior capsule using a slit lamp gauge. Each patient filled out a simple questionnaire about floaters. Preoperative and postoperative data were compared using the Pearson Chi-square and Student's t-test. Statistical analysis was performed with SPSS software (version 15.0; IBM Corp., New York, NY, USA). A P Pentamorphone in the study of which three were excluded due to missed follow-up visits. There were 45 (54.2%) right eyes and 38 left eyes. Mean patient age was 63.2 �� 6.6 years (range, 49 to 79 years). The hinged group was comprised of 43 eyes, and there 40 eyes in the conventional group. All eyes had undergone phacoemulsification with IOL implantation. Mean duration between cataract surgery and YAG capsulotomy was 19.8 �� 11.6 months (range, 4�C72 months). Based on the EPCO grading system; 15 patients (18.1%) had Grade 1 PCO; 31 patients (37.3%) had Grade 2 PCO; 22 patients (26.5%) had Grade 3 PCO and; 15 patients (18.