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A single institution retrospective review identified all patients undergoing heart transplant at ��18?yr of age from 1987 to 2010 who survived ��1?yr. Using medical record and database review, patients were evaluated for development of autoimmune or severe allergic disease. Of 129 patients who met criteria, seven patients (5.4%) with autoimmune or severe atopic disease were identified. Immune-mediated diseases included inflammatory bowel disease (n?=?3), eosinophilic esophagitis/colitis (n?=?4), and chronic bullous disease of childhood (n?=?1). Patients ROR1 Further study is needed to determine risk factors for the development of immune-mediated disease to identify best practices to decrease incidence. ""Sensitization to HLA is a risk factor for adverse outcomes after heart transplantation. Requiring a negative prospective CM results in longer waiting MK 2206 times and increased waitlist mortality. We report outcomes in a cohort of sensitized children who underwent transplant despite a positive CDC CM+ using a protocol of antibody depletion at time of transplant, followed by serial IVIG administration. ABT263 All patients