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We found a high prevalence of GORD both in those with confirmed VCD (77.1%) and in the high-probability I-BET151 solubility dmso VCD group (92.6%). However, proton pump inhibition only marginally improved VCD symptoms. This reflects the complex relationship between GORD and VCD, where the acid content of the refluxate forms only part of the picture. Further understanding of this relationship is required to develop more effective therapy. ""367" "The authors wish to bring to the readers' attention an error in page 72 of the TSANZ Poster Abstract section published in the abstract supplement issue of Respirology. The correct title of TP-123 should read as follows: MUTATIONS IN HEDGEHOG PATHWAY GENES PTCH1 AND SMO ARE RARE IN MALIGNANT MESOTHELIOMA CELLS The author apologizes for this error and any confusion it may have caused. ""368" "TAIKI FURUKAWA, HIROYUKI TANIGUCHI, YASUHIRO GSK2656157 cost KONDOH, TOMOKI KIMURA, KENSUKE KATAOKA, TOSHIAKI MATSUDA, TOSHIKI YOKOYAMA Department of Respiratory Medicine and Allergy, Tosei General Hospital, Seto, Aichi, Japan Background and Aim of Study?Recent studies have clarified predictors of survival in idiopathic pulmonary fibrosis (IPF), however, the impact of health-related quality of life (HRQL) on survival has not fully been studied until now. The aim of the study was to investigate relationships between HRQL and survival in IPF. Methods?We retrospectively analyzed the initial evaluation data of consecutive IPF patients who underwent multidimensional evaluation including the HRQL scoring of the St. George's Respiratory Questionnaire (SGRQ) from June 1, 2004 to June 1, 2012. Cox proportional hazard analyses were performed to examine the relationship between HRQL scores and survival. Results?118 patients (102 men, 63 with surgical lung biopsy, mean age 65.7?��?7.7 years) were studied. The median survival time was 47.4 (95% CI 37.3�C57.4) months. The mean PaO2, FVC % predicted, DLco % predicted, and mean pulmonary artery pressure (MPAP) were 82.6?��?11.4?mmHg, 78.3?��?20.1%, 56.4?��?19.6%, and 17.1?��?5.5?mmHg, respectively. The 6-min walk distance (6MWD) and the lowest SpO2 of the 6-min walk test (6MWT) were 570?��?126?m, 17-DMAG (Alvespimycin) HCl 82.4?��?9.6%, respectively. The symptoms, the activity, the impacts, and the total score in the SGRQ (SGRQ total) were 45.9?��?22.5, 42.6?��?24.4, 28.5?��?19.8, and 36.0?��?20.0, respectively. By univariate Cox proportional hazards analysis, the symptoms, the activity, the impacts, and the total score in the SGRQ were significant prognostic factors. BMI, PaO2, FVC % predicted, FEV1/FVC, DLco % predicted, Baseline Dyspnea Index, 6MWD, lowest SpO2 during the 6MWT, MPAP, and CT pattern with definite UIP were significantly associated with survival. Multivariate Cox analysis showed FVC % predicted (HR: 0.972, 95% CI: 0.958�C0.986, p?
