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Moreover, P-selectin expression in Akita gingival tissues was elevated compared with that of WT. Conclusion:? Chronic hyperglycemia induces a proinflammatory state in the gingival microcirculation characterized by increased vascular permeability, and leukocyte and endothelial cell activation. Leukocyte-induced microvascular BGJ398 cost damage, in turn, may contribute to periodontal tissue damage in diabetes. ""Alkan EA, Parlar A. EMD or subepithelial connective tissue graft for the treatment of single gingival recessions: a pilot study. J Periodont Res 2011; 46: 637�C642. ? 2011 John Wiley & Sons A/S Background and Objective:? The combination of EMD with root-coverage procedures has been shown to promote periodontal regeneration on the exposed root surface. The aim of this randomized clinical study was to compare the efficacy of EMD with connective tissue graft (CTG) for the treatment of Miller Class I and Class II single recessions in a split-mouth design. Material and methods:? The study included 12 systemically healthy patients, each with two single bilateral gingival recession defects (24 recessions). One recession defect in each patient was treated with the coronally advanced Unoprostone flap (CAF)?+?EMD procedure and the other recession defect was treated with the CTG + EMD procedure, in a split-mouth study design. The parameters recession depth (RD), recession width, percentage of root coverage, height of keratinized tissue (HKT), gingival thickness, probing depth and clinical attachment level (CAL) were recorded at baseline. All parameters, except for gingival thickness, were remeasured at 6 and 12?mo. Results:? The mean percentage root coverage at the final evaluation was 92?��?14% for the CAF?+?EMD group and 89?��?14% for the CAF?+?CTG group. Both treatments resulted in statistically significant (p?Protease Inhibitor Library in vivo significant decrease in the probing depth and a significant gain in the CAL for both groups. The probing depth was statistically higher in the CAF?+?CTG group than in the CAF?+?EMD group at 6?mo (p?
