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The original CCC study reported a best cut-off of 132 to discriminate between children with typical SLI and those with PLI.[7] The study confirmed that the cut-off of 132 remained the most acceptable sensitivity and specificity. The clinical subjects in the Bishop CCC study[7] were different from the present study in terms of age range and diagnosis. Despite these differences, the present Thai study Stem Cells antagonist using ROC analysis found that the same cut-off scores optimally discriminated pragmatic impairments in children with ASD from children with typical development. This cut-off can differentiate only children with PLI from typically developing children, not from those with SLI. Therefore, further research is required in the wide range of language disorders samples. The present study found that children with ASD can be differentiated from typically developing children in terms of pragmatic language skills based on the CCC-Thai. This instrument demonstrated acceptable sensitivity and specificity with high PPV and NPV. Therefore, the CCC-Thai is a useful instrument to detect PLI in Thai children with ASD, but cannot be used as a diagnostic instrument. In the present Thai study we had a heterogeneous sample with regard to children's ability. Therefore we used the VABS to obtain a standardized measure buy BI 2536 of adaptive functioning. Although the VABS score of adaptive functioning might not exactly represent children's IQs, it is closely correlated with cognitive level (verbal IQ, performance IQ, full-scale IQ or mental age).[12-14] BML-190 In the present study, 76% of children with ASD had low-functioning ASD (VABS score