The results indicate that miR-302b is definitely an crucial miRNA associated towards the inhibition of cancer progenitor cells caused by Ascl2 selective blockade in HT-29 cells

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Two mouse retinal degenerations caused by missense mutations in the beta-subunit of rod cGMP phosphodiesterase gene. Vision Res 47: 624633. 35. Reme CE, Grimm C, Hafezi F, Marti A, Wenzel A Apoptotic cell death in retinal degenerations. Prog Retin Eye Res 17: 443464. 36. Tan E, Wang Q, Quiambao AB, Xu X, Qtaishat NM, et al. The partnership between opsin overexpression and photoreceptor degeneration. Invest Ophthalmol Vis Sci 42: 589600. 37. Wang M, Lam TT, Tso MO, Naash MI Expression of a mutant opsin gene increases the susceptibility from the retina to light damage. Vis Neurosci 14: 5562. 38. Hao W, Wenzel A, Obin MS, Chen CK, Brill E, et al. Proof for two apoptotic pathways in light-induced retinal degeneration. Nat Genet 32: 254260. 39. Concepcion F, Chen J Q344ter mutation causes mislocalization of rhodopsin molecules that are catalytically active: a mouse model of Q344terinduced retinal degeneration. PLoS 1 5: e10904. 40. Tam BM, Xie G, Oprian DD, Moritz OL Mislocalized rhodopsin will not need activation to lead to retinal degeneration and neurite outgrowth in Xenopus laevis. J Neurosci 26: 203209. 41. Smith LE Bone marrow-derived stem cells preserve cone vision in retinitis pigmentosa. J Clin Invest 114: 755757. 42. Zhang L, Insel PA The pro-apoptotic 1418741-86-2 protein Bim is often a convergence point for cAMP/protein kinase A- and glucocorticoid-promoted apoptosis of lymphoid cells. J Biol Chem 279: 2085820865. 43. Farrar GJ, Kenna P, Jordan SA, Kumar-Singh R, Humphries MM, et al. A three-base-pair deletion in the peripherin-RDS gene in one particular form of retinitis pigmentosa. Nature 354: 478480. 44. Weiss ER, Hao Y, Dickerson CD, Osawa S, Shi W, et al. Altered cAMP levels in retinas from transgenic mice expressing a rhodopsin mutant. Biochem Biophys Res Commun 216: 755761. 45. Nir I, Haque R, Iuvone PM Regulation of cAMP by light and dopamine receptors is dysfunctional in photoreceptors of dystrophic retinal degeneration slow mice. Exp Eye Res 73: 265272. 46. Paquet-Durand F, Azadi S, Hauck SM, Ueffing M, van Veen T, et al. Calpain is activated in degenerating photoreceptors inside the rd1 mouse. J Neurochem 96: 802814. 47. Johnson LE, van Veen T, Ekstrom PA Differential Akt activation in the photoreceptors of typical and rd1 mice. Cell Tissue Res 320: 213222. 48. Azadi S, Paquet-Durand F, Medstrand P, van Veen T, Ekstrom PA Upregulation and increased phosphorylation of protein kinase C delta, mu and theta in the degenerating rd1 mouse retina. Mol Cell Neurosci 31: 759773. 49. Hauck SM, Ekstrom PA, Ahuja-Jensen P, Suppmann S, Paquet-Durand F, et al. Differential modification of phosducin protein in degenerating rd1 retina is associated with constitutively active Ca2+/calmodulin kinase II in rod outer segments. Mol Cell Proteomics five: 324336. 50. Azadi S, Johnson LE, Paquet-Durand F, Perez MT, Zhang Y, et al. CNTF+BDNF therapy and neuroprotective pathways inside the rd1 mouse retina. Brain Res 1129: 116129. 51. Allagnat F, Alonso F, Martin D, Abderrahmani A, Waeber G, et al. ICER-1gamma overexpression drives palmitate-mediated connexin36 downregulation in insulin-secreting cells. J Biol Chem 283: 52265234. 52. Tsujikawa M, Wada Y, Sukegawa M, Sawa M, Gomi F, et al. Age at onset curves of retinitis pigmentosa. Arch Ophthalmol 126: 337340.