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Duloxetine and pregabalin patients averaged 12 to 13 outpatient office visits, 0.8 emergency room visits, 0.27 inpatient admissions, and 1.1 to 1.2 total hospital days. Pregabalin patients were slightly more likely to have a pre-index inpatient admission CAL-101 concentration than duloxetine patients (14.9% vs. 11.4%, P?=?0.048). The total healthcare costs were also similar ($18,970 for duloxetine vs. $19,019 for pregabalin, P?=?0.994) per study design, with most of the costs from outpatient ($9,978 for duloxetine vs. $9,711 for pregabalin, P?=?0.951), followed by pharmacy ($4,904 for duloxetine vs. $5,050 for pregabalin, P?=?0.868). Figure?1 presents the utilization of duloxtine and pregabalin over the 12-month post-index period. The mean total supply days were 239.6 days for duloxetine among duloxetine-treated patients, and 182.7 days for pregabalin among pregabalin-treated patients (P?Sitaxentan except skeletal muscle relaxants and topicals, where the use among duloxetine-treated patients was significantly less. Not surprisingly, duloxetine patients had more costs for antidepressants whereas pregabalin patients had more costs for anticonvulsants. Among all the other medications examined, the largest cost difference was for opioids ($1,268 for duloxetine selleck products vs. $1,839 for pregabalin, P?=?0.047). The healthcare utilization and costs over the 12-month post-index period were very different between duloxetine and pregabalin patients (Table?5). Duloxetine-treated patients had significantly fewer total hospital days (0.63 vs. 1.33, P?=?0.0495), outpatient office visits (11.0 vs. 13.5, P?=?0.041), and emergency room visits (0.6 vs. 0.9, P?=?0.047) than pregabalin-treated patients. Patients who initiated duloxetine had $7,667 lower total healthcare costs than those who initiated pregabalin ($19,378 vs. $27,045, P?=?0.030), with most of the cost differences from outpatient ($7,552 vs. $10,643, P?=?0.023) and inpatient ($2,351 vs. $4,868, P?=?0.036). Differences in outpatient costs between duloxetine and pregabalin patients were mainly from outpatient hospital ($3,438 vs. $4,953, P?=?0.040) and physician office visits ($2,476 vs. $3,485, P?=?0.034).