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It is a safe, non-invasive, effective, and swift method of analgesia, and the potential adverse reactions of other methods of pain control are eliminated.[3] The purpose of this study was to determine the effectiveness of TENS CP-673451 in vitro as an adjuvant modality in the management of pain in TMD patients and to compare the effectiveness of the adjuvant TENS therapy with that of analgesic therapy in patients with TMD. MATERIALS AND METHODS The present study was carried out in the Department of Oral Medicine and Radiology, over a period of one-and-a-half years, on subjects reporting to the Dental Outpatient Department (OPD). Ethical clearance was acquired from the Ethical Committee of the Yenepoya Medical College, Yenepoya University, before the onset of the study. A total of 40 patients with a clinical symptom of pain associated with TMD were included in the study. Patients with a history of maxillofacial trauma, orofacial infections, and developmental anomalies of the maxillofacial region were excluded. General contraindications of the TENS therapy, such as, the presence of a cardiac pacemaker or a serious/unstable heart condition, epilepsy or allergy to adhesive tape or electrodes of the TENS machine were also considered as exclusion criteria. The selected patients were randomly allocated into two equal groups. Prior informed consent was taken from all the Ergoloid patients. The patients in Group A were treated with medication [combination of analgesics and muscle relaxants �� (ultrazox tablet-chlorzoxazone 250 mg, diclofenac potassium 50 mg, paracetamol 325 mg; manufactured by Ranbaxy Laboratories Ltd, Gurgaon, India) thrice daily, for five days], while patients in Group B were subjected to TENS (TENS machine manufactured by Bharat Medical Systems, Chennai, India) therapy in two sessions of 30 minutes each, separated five days apart, along with the above medication. The intensity of the pain was assessed using the Visual Analog Scale (VAS) before and after the treatment and the values were recorded. All the data www.selleckchem.com/p38-MAPK.html obtained from all the patients were subjected to statistical analysis. Student's paired and unpaired t tests were used. A P value