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An extension of the timing of the main outcome measure in future iterations of the trial will allow for the assessment of any sustained effect on outcomes. The results from this trial will provide information regarding the potential of a novel theoretical approach to online interventions for CrF in post-treatment cancer survivors. The research seeks to create supportive online environments at home to ameliorate fatigue, and promote self-management of symptoms in this group. Any amendments or updates to this protocol will be lodged with the journal such that it links them to this protocol document. This will allow all future trial publications and conclusions to be assessed against the extent to which we have adhered to the protocol. Trial status The trial and recruitment is ongoing. Footnotes Twitter: Follow Teresa Corbett at @Treasa_corbett Contributors: TC conceived of the study, its design and coordination, and drafted DDR1 the manuscript. JCW, AG, RM-M and BEM participated in the design of the study, and revisions to the manuscript. All authors read and approved the final manuscript. Funding: Cancer Care West Hardiman Scholarships, National University of Ireland Galway. Competing interests: None declared. Provenance and peer review: Not commissioned; http://www.selleckchem.com/products/cilengitide-emd-121974-nsc-707544.html externally peer reviewed. Data sharing statement: Further information available from first author.""Pressures on emergency departments (EDs) continue to rise in many developed countries, placing health systems such as England's National Health Service (NHS) under financial strain. Nearly half the NHS budget is spent on acute and emergency care, and children are among the highest users. Around 10% of those attending EDs are preschool children aged under 5?years.1 2 One-third visited an ED at least once in 2011/2012 (959?502/3?304?990).3 This number has risen by 40% in the past decade, and is associated with an increase in emergency hospital admissions.4 Up to 40% of ED attendances are believed to be ��inappropriate�� particularly among young children,2 and it is estimated that 10% of infants (aged selleck products Children living in deprived areas are more likely to attend EDs,9 particularly out of hours and where access to primary care is poor.3 10 Urgent care centres (UCCs) were first introduced in England in 1999 with the aim of reducing the number of inappropriate ED attendances.11 From this, various models have developed, including GP-led UCCs colocated with EDs, which provide access to GPs outside of ��normal working hours��. This UCC model is the current recommendation by the Royal College of Paediatrics and Child Health, alongside the Royal College of Physicians and Royal College of Surgeons.