The Sluggish Man's Solution To The Temozolomide Triumph

The time �� treatment interaction term tested whether the within�\rat change over time differed depending on the treatment group. Results Effects of PDTC on body weight and kidney enlargement Animal health and body weight Treatment with PDTC was well tolerated in Lewis and LPK rats and there was no mortality during the study. All treatment groups gained body weight at the same rate and there was no difference in body weight among groups at the end of the study (Table 1). Table 1. Effects of PDTC on body weight, renal function, and proteinuria in Lewis and LPK rats. Assessment of TKV and cyst volume by MRI At week 5, MRIs showed that the kidneys of LPK rats were reniform in shape and enlarged (Fig. ?(Fig.2A2A and B). On axial and coronal DDR1 T2�\weighted MR images, the kidney cortices of LPK rats were hyperintense compared to normal kidneys, indicating a higher fluid content. At week 10, LPK kidneys retained the reniform shape but were learn more increased in size compared to week 5 (Fig. ?(Fig.2C2C and D). At this time point, the cortex was hyperintense, along with multiple, loculated hyperintense regions throughout the inner and outer medulla, suggesting that cystic dilatations had developed in the collecting ducts. By quantitative analysis, the relative within�\rat increase in TKV from week 5 to week 10 was 1.3�\fold greater in the LPK + vehicle group compared to LPK + PDTC (40 �� 2) (95% CI 1.10�C1.60�\fold, P = 0.010, Fig. ?Fig.3A).3A). In addition, the relative within�\rat increase in absolute cyst volume from week 5 to week 10 was 1.4�\fold higher in the LPK + vehicle group compared to LPK + PDTC(40 �� 2) (95% CI 1.20�C1.72�\fold, P treatment resulted in a significantly higher within�\rat change in TKV and absolute cyst volume. ... Kidney to body weight ratio (KW:BW) At the time of euthanasia, LPK kidneys were enlarged, pale, and fluid�\filled. The KW:BW in vehicle�\treated LPK rats was increased 9�\fold compared to vehicle�\treated Temozolomide Lewis rats (LPK + vehicle 6.4 �� 0.7, vs. Lewis + vehicle 0.7 �� 0.1%, P