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A CYTH4 trial of metal dilatation should be given before proceeding to fistula closure. Mild steroid based ointment improved quality of graft in patients in whom graft was uneven. The two-stage Bracka repair reconstructs the new urethra from a free preputial skin graft and it is reliable and easily reproducible technique with very good cosmetic results. Footnotes Source of Support: Nil Conflict of Interest: None declared.This was a prospective observational study conducted over a period of 1.5 years between January 2013 to June 2014. All patients of antenatally diagnosed hydronephrosis were included. Patients with parental refusal to consent and disappearance of hydronephrosis on 3rd trimester ultrasound were excluded. Twenty fetuses with normal ultrasound served as controls. Ethical clearance was obtained and patients Selleckchem Erlotinib were enrolled from Obstetrics and Gynecology Outpatient Department (OPD). All the patients were followed up with serial ultrasounds till delivery and severity of hydronephrosis was assessed using the Society of Fetal Urology (SFU) grading [Table 1]. In patients with bilateral hydronephrosis, the higher grade was taken into account while performing the analysis. Two milliliter of cord blood was collected for PRA estimation at the time of cord clamping in ethylenediaminetetraacetic acid (EDTA). Ultrasonography kidney ureter, bladder (USG KUB) to confirm hydronephrosis and baseline renal function tests (RFT) were done at 48 hours of birth. Diagnosis of PUV was confirmed by micturating cystourethrogram (MCU) done soon after birth. Accordingly, patients were divided into two groups: PUV and those with hydronephrosis due to vesico-ureteric reflux and pelvi-ureteric junction obstruction (non-PUV). Patients diagnosed as PUV were managed according to our current clinical practice and published protocol.[1] All the patients were kept under close follow-up. PRA was repeated at 1 month post-operatively. All PUV patients were followed up with MCU, glomerular mTOR inhibitor filtration rate (GFR) and Tc-99m dimercaptosuccinic acid (DMSA) scan at 1 and 6 months post-operatively. PUV patients were divided into two groups based on GFR values at 6 months post-operatively �� those with a GFR