The Self-Defense Skill Related To Temsirolimus

2;q12)[20],+del(9)(q22)[17],de l(18)(q21)[13] Figure 2. Complex karyotype with multiple chromosomal aberrations: 46-48,XY, add(4)(q?), del(4)(p?), del(5)(q23), add(6)(p23), del(7)(q22), t(8;9)(p11.2;q12), +del(9)(q22), del(18)(q21). Hospital course The patient was treated with a standard induction (7+3) chemotherapy regimen consisting of daunorubicin 45 mg/m2 daily for 3 days and cytarabine 100 mg/m2 daily continuous infusion for 7 days. Blood and platelet transfusions were administered during induction period. On post-induction day 28, the bone marrow biopsy showed hypercellular marrow with 38% residual erythroblasts. Cytogenetics showed persistent multiple chromosomal abnormalities. He was re-inducted again with FLAG regimen (fludarabine + high-dose cytarabine + G-CSF). He failed to tolerate the treatment and died after 10 days due MRIP to severe pulmonary infection. Discussion Pure erythroid leukemia is exceedingly rare type of AML representing find more of all AML cases and 13% of acute erythroid leukemia cases.1 It is a neoplastic proliferation of immature cells committed exclusively to the erythroid lineage comprising at least 80% of bone marrow cells with no evidence of a significant myeloblastic component.2 Clinically, PEL patients present usually with profound anemia symptoms such as weakness and pallor, fever and hemorrhages.3 Presence of hepatosplenomegaly varies between 20 to 40% of the series.3,4 There are few reported cases of extramedullary pure erythroid leukemia involving lymph nodes or presenting as a hemangioma.5,6 Our patient presented with PEL post heavy alcohol abuse over a prolonged time period that may indicate presence of some kind of causal relationship, an observation consistent with previous reports.7,8 Because of the extreme rarity of PEL, few studies have examined its pathogenesis and genetic features. There are no clear identifiable risk factors. However, rare cases of de novo familial PEL, buy PD173074 being autosomal dominant, have been reported.9,10 A number of available studies have revealed complex karyotype with predominance of -5/del(5q), -7/del(7q) and +19p.1,7,8,11-13 In a study conducted by Liu et al., all PEL patients (n=16) showed an extremely complex karyotype, with a median of 12 abnormalities (range 3-37). These abnormalities most frequently involved chromosomes 5 (69%), 7 (56%), 17 (44%), and 19 (38%).1 Cytogenetic study for the present patient revealed an extreme complex karyotype with 8 chromosomal abnormalities. Beside the most commonly reported abnormalities, such as del(5q) and del(7q), our patient had a novel translocation t(8;9)(p11.2;q12) in all the examined metaphases. To the best of our knowledge, this translocation has never been reported in acute myeloid leukemia in the past. Unfortunately, we were not able to perform a higher molecular study in order to clarify the origin of this abnormality.