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4%) were satisfied with acarbose/metformin FDC treatment. Some anti-diabetic drugs are known for their weight-gaining effect.[7] However, in this study the mean (SD) weight was reduced by ?1.7 (2.2) kg from baseline to the final visit. A comparative study by Jayaram, et al.[6] evaluated the safety, tolerability and benefits of acarbose/metformin FDC versus metformin alone in T2DM patients from India. The mean reduction in FBG, PPG and HbA1c after treatment with acarbose/metformin FDC was 45.4 mg/dl, 91.4 mg/dl and 1.7%, respectively. The FDC associated improvement in glycemic control was superior as compared to metformin group. According to the physician's global assessment, 91.8% of the patients showed excellent to good tolerance for acarbose/metformin FDC treatment and the tolerability were comparable to metformin monotherapy in the same study. Another 16-week, randomized, find more double-blind, parallel-group, phase-3 study[8] was conducted at 13 sites in Taiwan, to compare the efficacy and safety Rho inhibition of acarbose plus metformin FDC versus acarbose monotherapy for T2DM. 233 were randomized (117 acarbose/metformin FDC: 116 acarbose) after a 4 week run-in with acarbose monotherapy (50 mg thrice-daily). These data show that in T2DM patients with unsatisfactory glycemic control, treatment with acarbose/metformin FDC for 16 weeks significantly reduced HbA1c, FBG, and 2-hour PPG (?0.75%, ?25.7 mg/dL, ?38.5 mg/dL, respectively, all P on glycemic parameters (HbA1c, FBG, and PPG) in real life clinical settings. In a study by Rosenstock et al. (1998),[9] it was observed that the addition of acarbose in patients with T2DM who are inadequately controlled with metformin and diet was safe and generally well tolerated and significantly lowered Fossariinae HbA1c, FBG, PPG and insulin levels. Further, a study by Phillips et al. (2003)[10] suggested that addition of acarbose to metformin monotherapy provides an efficacious and safe alternative for glycemic improvement in overweight T2DM patients inadequately controlled by metformin alone. A meta-analysis by McIntosh et al. (2011) assessed efficacy of all available classes of oral antidiabetic drugs (OAD) in patients with type 2 diabetes inadequately controlled by metformin monotherapy. The systematic review concluded that when combined with metformin, ��-glucosidase inhibitors resulted in HbA1c reduction similar to other OAD classes; however, AGIs show modest benefits without increasing bodyweight or risk of hypoglycemia.[11] In the present study, subgroup analysis for known cases and newly diagnosed cases of diabetes showed a significant reduction in FBG, PPG, HbA1c and body-weight (P
