The Most Important KU-55933 Traps

9, 5.3] = 1.3, P = 0.272). Additionally, the range of the fat fraction in the whole liver increased as the value of the fat fraction in the peripheral region of S5 on CSI increased (Pearson correlation = 0.654, P CYTH4 content is essential preoperatively. Because it is well known that distribution of fat is uneven in the liver, it is questionable whether a liver biopsy and imaging studies to quantify fat content in a small area of the liver can reflect the rest of the liver exactly. With the development of MRI techniques for evaluation of fat content, such as CSI and MRS, we can quantify fatty change in the liver noninvasively. Considering that donor safety is paramount in living donor LT, if a noninvasive imaging technique such as CSI or MRS can measure the precise amount of fat in the whole liver, it would be a useful workup tool for living liver MK1775 donor candidates. Until now, there have been only a limited number of studies exploring the utility of such techniques in preoperative evaluation of living liver donors [13,18,19]. The results of this study show that there is a linear relationship between the fat fraction measured with CSI in the peripheral region of S5 (biopsy site) and histological fatty change on biopsy. This means that fat fraction of the liver estimated from CSI reflects the regional pathologic fatty change directly, as several papers which demonstrated the value of CSI or MRS for evaluation of hepatic steatosis in the general population have pointed out [4,11,13,20]. MRS and CSI are accurate methods to estimate hepatic fat fraction because they exploit differences in resonance frequencies of fat and water signals. However, KU-55933 in vitro MRS has several limitations: First, it cannot estimate the fat fraction in several regions of the liver at one time. Second, the region to be estimated is usually limited to a small area. Third, its signal can be influenced by hepatic iron content. In this context, previous studies have demonstrated that CSI using a modified Dixon method for quantification of fat in the liver may overcome these limitations. It has the advantages of easy manipulation, whole liver coverage, minimal vulnerability to iron content, and the absence of radiation.