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Results on continuous measurements were presented on Mean �� SD (Min-Max) and results on categorical measurements were presented in Number (%). Significance was assessed at 5% level of significance. Results In-Vitro: Diffusion Study: In-vitro release of curcumin gel assessed by UV spectophotometry showed 16.30% release of curcumin in 24 hours [Table/Fig-6]. At the end of 7th day the drug release was approximately 69.44%. [Table/Fig-6]: Diffusion Data of Pure Curcumin Gel (1%) Results were compared for both www.selleckchem.com/products/ZSTK474.html the groups at four different time interval after subgingival delivery of curcumin over a period of 1, 3 and 6 months from baseline. On analysing the Plaque index, it was seen that both the test and control groups led to significant intragroup reduction in plaque scores from baseline to 1, 3, and 6 months. On intergroup comparison, it was observed that no significant reduction at baseline and one month readings was present (p=0.153), (p=0.183) however, the results were highly significant at three month and six months interval (p=0.050, p=0.016) [Table/Fig-3]. On analysing the bleeding index, it was seen that both the test and control groups led to significant intragroup reduction in plaque scores from baseline to 1, 3 and 6 months. On intergroup comparison, it was observed that no significant reduction at baseline reading for both the groups (p=0.161), with highly significant results at 1,3 and 6 months interval (p=PRT062607 nmr seen that both the test and control groups led to significant intragroup reduction in plaque scores from baseline to 1, 3 and 6 months. On intergroup comparison, it was found that there was no significant reduction at baseline reading for both the groups (p=0.096) however, highly significant results at 1,3 and 6 months interval (p=Biperiden HCl Microbiological parameters included identifying the presence of four periodontal pathogens that is P.gingivalis, P. intermedia, Capnocytophaga and Fusobacterium sp at baseline, 1, 3 and 6 months interval. On analysing P.gingivalis, it was seen that both the test and control groups led to significant intragroup reduction in their score from baseline to 1, 3 and 6 months interval. On intergroup comparison, it was analysed that the baseline reading for both the groups were insignificant (p=0.656), but highly significant reduction at 1, 3 and 6 months interval was seen (p=