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In relation to peripheral T cells, we found a decrease in the percentages of CD3+ CD4+ cells at the time of diagnosis that attained normal values upon starting specific treatment (data not shown). When assessing the frequency of Tregs throughout specific treatment, these cell populations remained significantly increased during that period compared to values in HCo, reaching their highest relative levels at T4 (HCo versus T4 P Crenolanib concentration Box plots show median values, 25�C75 percentiles of data in each group with maximum and minimum values. HCo: healthy controls. T0: ... 3.3. Correlations between Treg Frequency and Cytokine and Hormone Levels TGF-��, IFN-��, and IL-6 plasma levels were assessed at the beginning and at different Liothyronine Sodium time points during anti-TB treatment. Table 2 shows median values and interquartile range for each cytokine at the study time points. The three cytokines were increased at the time of diagnosis with respect HCo, returning to normal values once patients initiated specific treatment. Pairwise correlations between cytokines and Treg frequency revealed that IFN-�� levels were positively associated with % Treg at month two under treatment (R = 0.868, P Lapatinib four months of specific treatment (R = ?0.798, P