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Figure 2 provides a close-up illustration of the risk pattern for ages 18�C50 years. Overall, the risk of fracture increased continuously up to 8 years of age and remained unchanged between 6 and 11 years for both genders. From the age of 12, the risk of fracture increased gradually until the age of 19 in males, whereas the risk of fracture decreased over adolescent period for females. The risk of fracture declined in males from age 20 years through to the late 40s; among females, however, the risk of fracture began increasing from about the age of 42 years. Up to the age of 54 years, the incidence rate of fracture was consistently higher for males compared to females; thereafter, female rates exceeded male rates and remained higher http://www.selleckchem.com/products/ABT-737.html to the end of the observation period. Accordingly, the age-specific female-to-male incidence rate ratios of fracture increased from the age of 20 (Figure 3). The pattern of age-specific injury hospitalisation Hesperadin rates appeared to be similar between the two genders, except for ages 55 to 65, when the risk of injury continuously increased in females but remained largely unchanged in males (Figure 6). Figure 1 Gender-age-specific incidence rates of fracture hospitalisation. Figure 2 Gender-age-specific incidence rates of fracture hospitalisation for the age between 18 and 50 years. Figure 3 Age-specific female-to-male incidence rate ratios of fracture hospitalisations. Figure 6 Gender-age-specific overall injury hospitalisations rates. The age-specific rate of fracture (in natural logarithm form) in adults (>18 years) was well predicted by age at its 1st, 2nd, and 3rd power in males with an adjusted R-squared of 0.98 (p 0.8) with an adjusted R-squared of 0.99 (p learn more incidence rates of fracture hospitalisation and estimates from log-linear model (per 10,000 person-years). Table 1 log-linear model of age-specific fracture hospitalisation rates. For males and females, respectively, the cumulative risk of having at least one fracture hospitalisation due to injury was 11.8% and 6.3% by the age of 18 years, increased to 23.8% and 11.4% by the age of 45 years and increased again to 37.4% and 37.6% by 80 years (Figure 5). Figure 5 Cumulative risk of having any fracture hospitalisation since birth. 5. Discussion This study provided a detailed picture of the risk of fracture hospitalisations among the Western Australia population. Overall trends in age and gender specific risk of fracture were similar to observations from previous studies conducted on other populations [9�C14, 20, 24].