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Further two children died: One due to bleeding in the early post-operative course and one due to multifactorial causes (renal vein thrombosis, septicemia and bleeding) two?yr after transplantation. Glucocorticoids (steroids) were in total given to 19 (29%) recipients at some time with a median length in treatment of 12?months (range: 0�C61?months). The main reason for steroid treatment was clinical acute Fleroxacin rejection. The first year rejection rate was 9% (n?=?6). An additional 14% (n?=?9) of our patients had one or multiple late rejections. Rejection therapy with steroids typically lasted 3�C12?months. Histopathologically, all rejections were mild (Banff class 1a or 1b), none led to graft failure, and there were no humoral rejections. Four patients were treated with steroids for other reasons (HUS, FSGS, and asthma). A completely steroid-free regimen thus applied to 71% (n?=?46) of the patients. Eighty-two percent of the children (n?=?50/61) had a normal or subnormal BMI prior to transplantation. Ten percent (n?=?6/61) were overweight (BMI-SDS Luminespib ��1.04 and find more (16/61) by one?yr and 20% (12/61) two?yr after transplantation. As growth is highly age dependent, we divided the children into three age groups: 0�C5?yr, 6�C11?yr, and >12?yr. Height-SDS increased significantly in the youngest group from ?2.1 to ?0.9 over five?yr (t-test, p?=?0.02). In the older children, height-SDS showed an insignificantly increasing trend (Fig.?3). To investigate for a potential secular trend, all height measurements were plotted against time (1994�C2009); we could not demonstrate any change in height-SDS over time. To identify independent factors associated with change in height-SDS, we performed a multiple linear regression analysis with the following factors: steroid treatment time, age at transplant, one-yr eGFR, clinical acute rejection, BMI, and LRDT versus DDRT. This model demonstrated a significant inverse association between age at transplant and increasing height-SDS (p?