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This study was undertaken to evaluate patient/graft survival, function vis-a-vis SCr, rejection episodes, and mortality in DDRTx performed in 37 children between 1998 and 2011. The most common recipient diseases leading to ESRD were congenital anomalies of kidney and urinary tract (48.6%) and chronic glomerulonephritis IRS1 (18.9%). Mean recipient age was 13.8?��?3.1?yr; 67.5% (n?=?25) were men. Mean donor age was 38.8?��?18.6?yr; 48.5% (n?=?18) were men. Mean dialysis duration pre-transplantation was 15.5?��?3.5?months. All recipients received r-ATG, and triple immunosuppression. Over a mean follow-up of 3.93?��?3.5?yr, patient and graft survival rates were 72.9% (n?=?27) and 83.7% (n?=?31), respectively, with a mean SCr of 1.1?mg/dL; 21.6% (n?=?8) of patients had acute rejection episodes; 24.3% (n?=?9) of patients had DGF. A total of 27% (n?=?10) patients died, mainly owing to infections (n?=?6) and cardiovascular disease (n?=?3). DDRTx is a viable option for children and achieves acceptable JQ1 mouse graft function with patient/graft survival over long-term follow-up, encouraging use of this approach. ""Kathemann S, Lainka E, Baba HA, Hoyer PF, Gerner P. Gilbert��s syndrome �C a frequent cause of unconjugated hyperbilirubinemia in children after orthotopic liver transplantation. Pediatr Transplantation 2012: 16: 201�C204. ? 2012 John Wiley & Sons A/S. Abstract:? Gilbert��s syndrome is one major cause for unconjugated hyperbilirubinemia in healthy individuals with the prevalence being approximately 3.2�C8.6%. It is caused by a mutation in the promoter region of the UGT1A1-gene with a prolonged TAA-repeat coding for the enzyme bilirubin UDP-glucuronosyltransferase (A(TA)7TAA allele). After OLT, Gilbert��s disease of the transplanted liver can cause unconjugated hyperbilirubinemia. Therefore, we looked for the presence of A(TA)7TAA alleles in pediatric liver transplant recipients with unconjugated hyperbilirubinemia. Laboratory results of 106 pediatric liver transplant Rapamycin ic50 recipients (aged 0�C17?yr) were evaluated for elevated total bilirubin over 2.0?mg/dL (conjugated bilirubin