The Companies Seemed To Laugh About MMP23B - Now We Laugh At Them

2%) as the prominent compounds. On the contrary, the root oil contained ��-fenchyl acetate (37.6%), 1,8-cineole (15.6%) and camphene (13.6%) as the main constituents [Table 1].[11] According to Rout et al. (2005), the leaf oil contained 1,8-cineole (21.9-24.7%), ��-pinene (16.8-29.1%), camphor (4.9-8.0%), while the root oil had ��-fenchyl acetate (39.1-45.2%), 1,8-cineole (15.1-15.5%) and camphene Ibrutinib in vitro (9.0-12.3%) as the main constituents.[29] Other analysis of A. calcarata has displayed the presence of 4-O-methyl-syringic acid, methyl cinnamate, protocatechinic acid, quercetin, vanillic acid and several diterpenes and terpenes as the main constituents.[25] Most of the researchers reported the 1,8-Cineole as the major chemical component in the essential oil of A. calcarata.[21,23,30,31] However, rhizome oil constituents of A. calcarata from Bangladesh was found to contain ��-fenchyl acetate (51.4%) and 1,8-cineole (15.1%) as main constituents [Table 2].[27,32] Table 1 Constituents of Alpinia calcarata Venetoclax chemical structure rhizome essential oil (Arambewela et al. 2005) Table 2 Constituents of Alpinia calcarata rhizome essential oil (Bshuiyan et al. 2011) Pharmacological properties Antioxidative effects The antioxidative properties of cold ethanolic extract (CEE), hot water extract (HWE) and hot ethanolic extract (HEE) A. calcarata (Zingiberaceae) rhizomes were investigated by TBARS (thiobarbituric acid reactive substances) assay and DPPH (2,2-diphenyl-l-picrylhydrazyl) MMP23B free radical scavenging assay. Among the tested extracts, highest antioxidant potential was evident in CEE. In TBARS assay antioxidant potential of CEE was comparable to that of positive control BHT (butylated hydroxy toluene). On the other hand in DPPH assay the free radical scavenging ability of CEE was lower than BHT.[28] However, the researchers concluded the moderate antioxidant activity of A. calcarata rhizome at least in the above-mentioned in vitro studies. Hypoglycemic and anti-hyperglycemic effects Alpinia calcarata has been evidenced with potential antidiabetic effects. Two different groups of researchers have examined the antidiabetic effects of A. calcarata. Arambewela et al., investigated the effects of hot ethanolic extract and hot water extract in normal glycemic and streptozotocin (STZ)-induced diabetic rats with an oral administration of the extract.[15] In normoglycemic rats, administration (each dose in a volume of 1 mL DW) of a daily oral dose of 250, 500, 750, 1000 and 1500 mg/kg hot HEE and HWE significantly (P