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To reinforce this homogeneity, the PRIOAM team also selleck chemicals coordinated monthly training meetings with these advisors, which also served to monitor the progress of the programme. The acceptance of the programme was assessed using a voluntary anonymous questionnaire, in which the opinion of the interviewed clinicians regarding the usefulness of the CI was requested (Appendix S2). The objective of improving antimicrobial utilization was assessed with the CI (Appendix S1) and considered to be achieved if a significant increase in CI marks was recorded by the fourth trimester after the implementation of the ASP. Evaluations were performed not only for overall CI, but also specifically in each clinical department. The trend in overall and specific Otenabant antimicrobial consumption, measured as number of DDDs/1000 occupied bed-days, was also assessed during the same period. Only antibiotics and antifungals were included. DDDs were calculated following the Anatomical Therapeutical Chemical Classification/Defined Daily Doses (ATC/DDD) methodology recommended by the WHO. The indicators of this first objective were evaluated 3-monthly; results were fed back to the clinical departments and are presented here. Normal distribution of the sample was assessed using the Kolmogorov�CSmirnov test. Paired categorical and continuous variables were compared using the chi-squared test and Mann�CWhitney U-test, respectively. Significance was set at p?see more prescribed, representing 20.8% of all CIs (n?=?310), followed by glycopeptides, 11% (n?=?164), and carbapenems, 10.1% CI (n?=?150), as seen in Appendix S2 (supplementary data file). At the initiation of the programme, an overall rate of inappropriate antimicrobial treatments of 53% was observed (176 out of 332 CIs carried out during the first trimester). At this point up to 56% of surgical prophylaxis, 55.2% of empirical treatments and 46.6% of targeted treatments prescribed in the centre were considered to be incorrect. Excessive duration of treatment was the most frequent error (52.8%), followed by the choice of agent (38.6%).