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The clinical and biochemical characteristics at baseline and during follow-up for progressors and non-progressors are shown in Table 2. Duration of diabetes was significantly Protease Inhibitor Library solubility dmso longer in progressors compared with nonprogressors. Progressors tended to use of insulin therapy and ACEi or ARB at baseline more frequently than nonprogressors. The percentage of subjects taking other antihypertensive medication tended to be higher in progressors, with borderline statistical significance. Progressors had significantly higher levels of uric acid, hsCRP, UACR, and creatinine at baseline, but a lower eGFR compared with non-progressors. They had higher values of total cholesterol and TG at baseline, although the associations were borderline significant. Baseline ceruloplasmin levels were significantly higher in the progressors than in the non-progressors (262.6��40.9 mg/L vs. 233.3��37.8 mg/L, PUnoprostone and nonprogressors of diabetic nephropathy Kaplan-Meier analysis demonstrated Selleckchem BGJ398 a significantly higher incidence of progression of diabetic nephropathy according to baseline ceruloplasmin tertile (log-rank test, P