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Study 1: Haptoglobin polymorphism and susceptibility for the development of preeclampsia. Table 1 shows distribution of Hp phenotypes in a population of normotensive YES1 (normal blood pressure in pregnancy��NBPP) and hypertensive (Preeclampsia��PE) pregnant women (N = 265). The NT women were significantly younger (27.93 �� 4.91, mean �� S.D.) than women with preeclampsia (29.71 �� 5.97, mean �� S.D.) (P = 0.011). Most women have over 34 weeks of gestation, independently of hypertension degree, but before or 34 weeks of gestation there were more significantly preeclamptic women (30.3%) (P of Hp phenotype in all preeclamptic women at age of diagnosis between �� 34 weeks of gestation and > 34 weeks of gestation and we observed no significant differences (Table 2). Table 2 Distribution of Hp phenotypes in the sample of preeclamptic women (PE) stratified by age of gestation at diagnosis. Study 2: The susceptibility of cardiovascular risk in women with previous preeclampsia and the influence of risk biomarkers and its modulation by the Hp phenotype at long term Volasertib solubility dmso (2�C16 years). In the follow-up group we evaluated anthropometric and hemodynamic parameters and some biomarkers of cardiovascular risk in a sample of previously preeclamptic women and compared them with normotensive ones adjusted for age at pregnancy. We also study the influence of the Hp phenotype on the levels of biomarkers in circulation. 3.1. Anthropometric and Hemodynamic Parameters This sample consisted of 150 women aged 20 to 35 years old (min.: 20�Cmax: 47; 35.24 �� 5.48 (mean �� S.D.) and minimum BMI of 17.1 (underweight) to 42.7 (obesity) (26.39 �� 4.57Kg/m2, mean �� S.D.), who were recruited for this prospective study, Carboplatin mouse 2�C16 years after delivery. During pregnancy, 60 women were NT and 90 were preeclamptic. In this group, 16.2% have smoke habits and 4.7% consume alcoholic beverages, after pregnancy. In this sample, when evaluating the values of blood pressure and anthropometric data we observed significantly mean higher values in previously preeclamptic women (PE) for BMI (27.05 �� 4.79, P = 0.033), WC (89.54 �� 15.64, P = 0.004), systolic blood pressure (134.99 �� 16.50, P