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5 years; range, 21-87 years) who underwent whole-spine postmyelographic CT at our hospital before cervical surgery Kinase Inhibitor Library chemical structure between February 2006 and September 2012. Patients with cervical spondylotic myelopathy presented with only cervical spine symptoms (e.g., clumsiness of the hands, spastic gait, etc.) and not lumbar spine symptoms (e.g., lower-extremity pain, intermittent claudication, etc.) before cervical spine surgery. Patients were classified as DCS or non-DCS (n=40 each) if their spinal canal longitudinal diameter was BI 2536 Japan). Image data were obtained in 0.5-mm slices from the level of the occiput to the sacrum. 3. Image analysis Axial images from the thoracic to lumbar level were analyzed by 2 experienced physicians. The following parameters at the thoracic and lumbar level were analyzed: compressive lesions from the anterior part (i.e., disc herniation and osteophytes) (Fig. 1A), compressive lesions from the anteroposterior part (i.e., ligamentum flavum hypertrophy) (Fig. 1B), ligamentum flavum ossification (Fig. 1C), posterior longitudinal ligament ossification (Fig. 1D), and spinal cord tumors. A compressive lesion of the spinal cord or cauda equina was defined as a lesion in contact with the anterior or posterior spinal cord or cauda equina, a morphological deformity of the spinal cord, or the disappearance of the subarachnoid space. Isotretinoin In addition, ligamentum flavum and posterior longitudinal ligament ossification were defined as an ossified mass arising from the lamina, facet joints, or vertebrae. The numbers of affected cases as well as compressive and ossified lesions at each level of the spine were calculated. Fig. 1 (A) Compressive lesions in the anterior parts (i.e., disc herniation or osteophytes). (B) Compressive lesions in the anteroposterior parts (i.e., ligamentum flavum hypertrophy). (C) Ligamentum flavum ossification. (D) Posterior longitudinal ligament ossification. ... The data were analyzed with the ��2test. The level of significance was set at p