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The incidence of C.?tropicalis BSI during the study period was measured by use of the autoregressive integrated moving average test, with data in monthly intervals. This model was adjusted for the blood PCI-32765 research buy culture system used in each period and the percentage of blood cultures with growth of significant microorganisms (as a measurement of index of suspicion). A p-value PARP activity Stepwise logistic regression models were applied in the multivariate analysis to control for potential confounders and for risk factors of mortality. Variables with a p-value Thalidomide in 12 (6.7%), Candida dubliniensis in three (1.7%), Candida guilliermondii in two (1.1%), and Saccharomyces cerevisiae in two (1.1%). Patients with C.?tropicalis fungaemia were older (median, 67 vs. 56?years; p?0.01), had a higher incidence of cancer (49.2% vs. 32.8%; p?0.03) and had a lower incidence of HIV infection (5% vs. 17%; p?0.03) than controls (Table?2). No significant differences were found between the groups for other risk factors and clinical manifestations. The most common portals of entry were the abdomen among the cases (32.2% vs. 11.9%; p?0.001) and a venous catheter among the controls (23.7% vs. 44%; p?0.006). In 125 patients, the same Candida species was isolated from sites other than blood, with the same frequencies in cases and controls (49.2% vs. 54.2%; p?0.55).