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The significance level was set at P?TRIB1 methods. These fetuses and infants, ranging between 16 and 41 weeks of gestation, formed the basis for the ��normal�� lung volume/BW reference ranges shown in Table 1. Seventy-nine fetuses or infants who fulfilled the inclusion criteria, underwent standardized inflation, and had known or suspected risk factors for lung hypoplasia formed the basis for the determination of lung volume/BW values in association with lung hypoplasia (see below). Of the remaining 707 patients, 458 stillborns (65% of total) were excluded because of evidence of maceration, 85 liveborns (12%) were excluded because they lived more than 24?hr, 83 fetuses or newborns (12%) were excluded because they were outside of the age range at the time of death, and 81 fetuses or newborns (11%) did not undergo lung inflation for logistical or technical reasons. Mean lung volume increased 11-fold between 16 and 41 weeks' gestation, concomitant with a more than 16-fold increase in BW. As shown in Table 1, the lung volume/BW ratio remained strikingly stable between 16 and 32 weeks' gestation (canalicular and early to mid-saccular stages), ranging between click here 33.0 and 34.5?ml/kg over this 16-week time period. After 32 weeks, coinciding with late saccular/early alveolar stages, there was a gradual decrease in lung volume/BW ratio to reach a value of 23.4?ml/kg at term. Mean lung volume/BW was comparable in nonmacerated fetuses and age-matched newborns who lived selleck chemicals the various age groups. In concordance with the observed mean values, the 10th percentile range for lung volume/BW in preterm lungs between 16 and 32 weeks' gestation remained remarkably constant at around 26?ml/kg. At term, the 10th percentile value for lung volume/BW was 17?ml/kg. The lung volume/BW values of male and female patients were similar between 16 and 31 weeks' gestation, but appeared to diverge slightly from 32 weeks' on with a tendency to higher values in female fetuses and infants (differences not statistically significant).

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