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Serum IL-6, sIL-6R, and rheumatoid factor (RF) were assayed using appropriate enzyme linked immunosorbent assays (ELISAs) (IL-6 and sIL-6R, eBioscience, San Diego, CA, Pifithrin-�� clinical trial USA, and RF, Nittobo, Tokyo, Japan). The levels of TNF-��, IL-17A, IL-21, and IL-23 were measured using a multiplex bead immunoassay with Luminex laser based fluorescent analytical test instrumentation (Merck-Millipore, Darmstadt, Germany). All assays were conducted in duplicate. 2.3. Statistical Analyses Mann-Whitney U test was performed for group comparisons and Fisher's exact test was used for categorical variables. To examine the effect of baseline IL-17A levels on disease activity score 28 (DAS28) ESR response, analysis of covariance (ANCOVA) was used after adjusting for baseline DAS28 ESR, RF positivity, and levels of TNF-��, IL-21, and IL-23. A P value PDK4 Furthermore, 6.8% received TNF-�� buy RGFP966 inhibitors prior to commencement of the study. Table 1 Baseline clinical characteristics of the IL-17A low group and the IL-17A high group. 3.2. Baseline Serum Cytokine Levels and Changes in DAS28 ESR in Patients Who Did and Did Not Achieve Remission at 12 Weeks of TCZ Therapy Among the 44 patients, 14 (31.8%) patients achieved DAS28 ESR remission at 12 weeks of TCZ therapy and 30 (68.2%) patients did not. At baseline, IL-17A levels were significantly lower in the remission group than in the nonremission group (3.50 �� 2.94 versus 7.34 �� 3.34?pg/mL; P