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For multivariate analysis, a logistic stepwise backward regression was used. Categorical variables with p Docetaxel research buy From January 2005 to January 2009, 80 patients met the inclusion criteria. Most patients were diagnosed in 2007 and 2008 (35% and 36%, respectively).The mean age was 68?��?1 (range 39�C89) years and 84% were men. Other patients characteristics are shown Table?1. Of the 49 patients with peripheral arteritis, 26 had angioplasty and 11 underwent vascular surgery; there was no possibility of revascularization for the others. Of the patients, 37.5% had a past history of amputation as a result of vascular (16%), infectious (9%) or mixed (12.5%) causes. Amputation involved the first toe for 11%, other toes for 22.5%, the fore-foot for 2.5% and the limb for 2.5%. Of the patients, 47.5% had a history of hospitalization within 3?months before the bone sample was obtained. In 49% of cases, the infection involved a metatarsophalangeal (MTP) joint (Table?1). Seven (9%) had a calcaneum infection and ten (8%) had osteomyelitis after amputation because of arteritis. Twenty-one percent had visible, exposed bone or joint on physical examination. Fifteen patients had bone specimens sent for histology, which showed compatibility Vatalanib (PTK787) 2HCl with an infectious process. Only one patient (the only one who did not have any neuropathy) required a painkiller (morphine sulphate, 5?mg) before the bone specimen was drawn. There were 129 isolates obtained from bone cultures from the 80 patients, with a mean of 1.6?��?1 species per patient (Staphylococcus aureus: 33%; central nervous system: 14%; streptococci: 9%; enterococci: 12%; corynebacteriae: 4%; Gram-negative facultative aerobic rods: 12%; Pseudomonas aeruginosa: 8%; and anaerobes: 4%). Culture of bone specimen was positive in 96% http://www.selleckchem.com/products/EX-527.html of patients (Table?2), although half (n?=?42) of the patients received a course of antimicrobials within 14?days of bone sampling (Table?1). Of these 42 patients, 30 had severe deep infection of the foot and were initially treated by their general practitioners with a combination of antibiotics (quinolone and rifampicin in six patients, quinolone and another antibiotic in 15, and a combination of other antibiotics in nine). The 12 remaining patients received a single antibiotic. Forty-six percent of cultures were monomicrobial. Two bacterial species were found in 37.5% of bone cultures, three in 11%, and five in 1%. Two patients (2.5%) had negative cultures: both received antimicrobial treatment within 3?days before the bone sampling and were successfully treated with a 6-week course of oral therapy with no relapse after 18?months of follow-up. Methicillin-resistant S.