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5 second (FEV0.5/FIV0.5) as a measure of hyperinflation in sever COPD. Methods?Five male outpatients with COPD (83?��?4 age, forced expiratory volume in 1 second (FEV1) 39.1?��?7 % predicted), all ex-smokers and undergoing long-term oxygen therapy, were included. Measurements were obtained more than four times for the ratio of circulating neutrophil count to peripheral white blood cell count (neutrophil %), FEV1, FEV1%predicted, C-reactive protein (CRP) and FEV0.5/FIV0.5 from July 1, 2011, to July 31, 2012. Results?Neutrophil%(69.9?��?10.8 %) was significantly correlated with FEV0.5/FIV0.5 (0.79?��?1.23) (rs?=??0.56579, p?KU-55933 in vitro CRP(0.36?��?0.44?mg/dl) was not significantly correlated MK-1775 manufacturer with FEV0.5/FIV0.5. Conclusion?This report suggests that circulating chronically increasing Neutrophil% might be able to progress the lung hyperinflation in sever COPD. NAOKI IJIRI, YOSHIHIRO TOCHINO, KAZUHIRO YAMADA, NAOKO YOSHII, GAKUYA TAMAGAKI, FUMIHIRO NAGAYASU, KAZUHIRO ASAI, HIROSHI KAMOI, HIROSHI KANAZAWA, KAZUTO HIRATA Department of Respiratory Medicine Graduated School of Medicine, Osaka City University, Osaka, Japan Background?The Global Initiative for Obstructive Lung Disease (GOLD) 2011 update document on COPD bases on levels of dyspnea including CAT, exacerbation history and %FEV1.0, while the previous GOLD categorized disease severity according to %FEV1.0 only. Objectives?To assess the usefulness of CAT scores by using GOLD 2011 classification. Methods?We studied patients with COPD in our hospital between August 2008 and July 2011. They were classified to 4 groups in accordance with the GOLD2011. CYTH4 We compared CAT scores with clinical indicators of six minute walk test (6MWT) and pulmonary function test (PFT) between group A (mild, low CAT scores) versus B (mild, high CAT scores), C (severe, low CAT scores) versus D (severe, high CAT scores) and A+C (low CAT groups) versus B+D (high CAT groups). Clinical indicators of 6MWT included six minute walk distance (6MD) and desaturation area (DA), and PFT included %DLCO, maximal mid-expiratory flow (MMF) and ��N2. Results?The 60 COPD patients were examined. They were 72.9?��?7.5 years old and 86.7% were male. 19(32%) were classified as GOLD 2011 group A, 6(10%) group B, 15(25%) group C, 20(33%) group D. 6MD and %DLCO in Group D was significantly lower than in group C. 6MD, %DLCO and MMF in Group B+D was significantly lower than in group A+C. DA and ��N2 of Group D and B+D was higher than that of group C and A+C, respectively. There were no differences in all clinical indicators between group A and B. Conclusion?Our results suggested that exercise intolerance, desaturation on exertion and small airway obstruction might correlate with high CAT scores in COPD patients with low pulmonary function.