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Serum IGFBP-3 levels were measured by using an IRMA with an analytical sensitivity of 50 ng/mL, intra-assay CV of 4.6% to 10.2%, and inter-assay CV of 6.3% to 12.4% (IDS S.A, Belgium). 4. Analysis Categorical data were described as number (percentage) and continuous data were presented as the mean��standard deviation (SD). Comparisons between groups were performed by using independent-sample t-tests. Statistical significance was defined as pLapatinib solubility dmso and GraphPad Prism (version 5; GraphPad Software Inc, La Jolla, CA, USA). Specificity was defined as the number of true negative results divided by the total number of results. Accuracy was defined as the number of correct results divided by the total number of tests. RESULTS 1. Subjects' characteristics The clinical and laboratory data are summarized in Table 1. Of the 120 children who underwent the GH stimulation test, 83 children (69.2%) were diagnosed with GHD and 37 children (30.8%) were diagnosed with ISS. A total of 83 children (69.2%) were boys and 37 (30.8%) were girls. The mean age of the children was 9.99��2.60 years in the GHD group and 9.64��2.78 years in the ISS group. A total of 92 children (76.7%) were prepubertal (Tanner stage 1) and 28 children (23.3%) were pubertal (Tanner stage 2 or 3). The IGF-1 and IGFBP-3 level of the patients at the time of the stimulation test learn more showed no significant difference in either group. In the GHD group, the mean IGF-1 level was 171.86��96.95 ng/mL, similar to that in the ISS group (170.75��98.60 ng/mL, p=0.954). TABLE 1 Clinical and biochemical parameters of patients with GHD or ISS The mean body weight standard deviation score (SDS) of the GHD group was -1.59��0.11, which was higher than that of the ISS group of -2.31��0.14, S6 Kinase which was a statistically significant difference (p