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The aim of this study was to compare the frequency of non-occupational exposure to asbestos in younger compared with older NSW residents and to assess trends in these exposures. Methods:?Structured telephone interviews were conducted with adult subjects who have had lung surgery for various clinical PD98059 conditions. The interview questionnaire was designed to survey lifetime occupational and residential history, ��do it yourself�� (DIY) home renovation activities and other possible environmental exposures. Subjects ��40 years were compared with those Decitabine exposure 2 (5.3%) 8 (20.5%) 0.09 Childhood exposure 9 (23.7%) 10 (25.6%) 0.88 Ever lived with a potentially exposed worker 22 (57.9%) 29 (74.4%) 0.13 Ever lived in a house containing asbestos 17 (44.8%) 27 (69.2%) 0.03 Other non-occupational exposure 5 (13.2%) 8 (20.5%) 0.07 Occupational exposure 4 (10.5%) 7 (17.9%) 0.35 Conclusions:?Asbestos exposure during DIY home renovation is occurring in approximately 13% of the population in NSW, including those Tryptophan synthase Medicine, The University of Queensland, Brisbane, Australia, 2Department of Thoracic Medicine, The Prince Charles Hospital, Brisbane, Australia Aim:?A proportion of patients with mesothelioma respond to standard chemotherapy consisting of pemetrexed and platinum, but tumour responsiveness most often becomes blunted after several cycles. To discover circumventable mechanisms of loss of chemotherapeutic sensitivity by comparing expression of genes implicated in cancer drug resistance between platinum na?ve and platinum exposed mesothelioma cells. Method:?Four mesothelioma cell lines were exposed to stepwise increments of carboplatin until in vitro tolerance to carboplatin at 20?��g/ml was established. Control cells from each line were passaged in parallel without carboplatin. Cells were in log phase growth and culture medium was free of platinum for at least two days prior to sensitivity testing for carboplatin and extraction of RNA using Qiagen RNAeasy Mini kits.
